Neighbouring the Dolenjska winegrowing area, Bizeljsko-Sremic lies on the left (northern) bank of the Sava River. The soils here are a product of Miocene sediment decay mixed with materials eroded from neighbouring mountains. Rogaska Slatina is a famous spa in the area, with sources of thermal and mineral water, again a reminder of a lively geological past.
The climate is gentle since the area presents its mountainous "back" to the cold winds of the north. The south and southwest facing slopes along the Sava valley are considered to be the best viticultural sites of all Posavje.
Modra Frankinja reaches its best in this area - the phenomenal 1983 vintage is archived in the Oresje Castle, which houses the area's largest cellar. The best white wines are Sauvignon, Chardonnay, and Laski Rizling. The area grows a unique white vine, the autochthonous Rumeni Plavec, which ferments into an acid-rich wine used primarily for blending. This grape is grown in quantity only in the Bizeljsko-Sremic area and can not be found outside the Posavje region.
The area produces some characteristic blended wines: Bizeljcan is an aromatic, dry blend of Laski Rizling, Sauvignon, Rumeni Plavec, and Sipon; white Sremican is a dry blend of Laski Rizling, Sauvignon, and Rumeni Plavec; red Sremican is a dry red wine blended from Modra Frankinja, Zametna Crnina, and Laski Rizling - a somewhat rare combination since blending of red wines with white wines is quite uncommon in Slovenia.
Specialties of this area include white, rosé, and red sparkling wines produced in accordance with the Methode Champenoise and Tawny Port.